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There is nothing new about cigarette companies asking the government for particular regulation (see "Fighting the Tobacco Wars," June 16, 1997). Whelan points out that Philip Morris and others quietly lobbied for the requirement that cigarette packages list the surgeon-general''s warning, believing it would give them immunity from lawsuits. They also backed the 1970s law that banned TV ads because broadcasters were required to carry antismoking public-service announcements to counter them. And when research about the bad health effects of cigarettes first came out in the 1950s, unrestricted "fear advertising" of filtered cigarettes from upstarts such as Philip Morris resulted in a two-year, 9 percent decline in cigarette consumption, the largest drop to this day. The advertising "remind[ed] consumers constantly of the worrisome symptoms associated with smoking," wrote economist John Calfee, now at the American Enterprise Institute, in his important 1986 article, "The Ghost of Cigarette Advertising Past," in Regulation magazine.

DISCUSSIONNicotine replacement, in the form of patches, chewing gum, and aerosols, has been widely used to diminish nicotine deprivation symptoms in individuals launicacamerooncigars trying to stop smoking. launicacamerooncigars (22) Antidepressant drugs administered launicacamerooncigars for this purpose also have been evaluated. (23,24)Bupropion is the only antidepressant drug approved by the US Food and Drug Administration for the treatment of tobacco addiction. In the United States, there has been wide experience with the use of this drug, which has potential side effects in patients predisposed to seizures. (25,26) The risk of seizures is related to the patients'' predisposition, to the clinical situation (eg, head injury, brain tumor, alcohol abuse, or cocaine addiction), and to the concomitant medications launicacamerooncigars used (eg, insulin, antipsychotic medication, antidepressant medication, launicacamerooncigars or theophylline). Approximately 35% of patients receiving 300 mg/d bupropion have insomnia, and there have been no clinical trials establishing the safety of bupropion in patients launicacamerooncigars with cardiovascular disease. (27) On the other hand, nortriptyline has been shown to be an effective treatment. (17,18) The drug is well-known, having been widely used in several countries since the decade of the 1960s. In comparison to other tricyclic antidepressants, nortriptyline has several therapeutic advantages as follows: minimal night stimulation; low incidence of anticholinergic side effects; low incidence of orthostatic hypotension; and low risk of seizures. Nortriptyline should be used with caution in patients having cardiovascular diseases. The clinical experience in relation to this factor is large, and the risks have been established. (28,29) Among tricyclic antidepressants, nortriptyline has the lowest rates of side effects, with acceptance in the elderly population. The most common side effects are a dry mouth launicacamerooncigars and constipation.

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