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He had a whiff and gave them back to Nelson. "Nice box," he said with the understatement of a connoisseur.

The study by Hall et al, (17) which was another placebo-controlled, double blind, randomized study of 199 patients receiving nortriptyline, resulted in an initial abstinence rate at 10 weeks of 40% for patients receiving placebo and 70% for patients receiving nortriptyline. The methodology used in our study permitted adjustment in the doses according to the serum levels of the patients. sosa This may explain the higher success rates in that study compared to those in our study. Hall et al (17) separately analyzed the rates of smoking cessation in patients with and without previous histories of major depression, receiving or not receiving behavioral or educational intervention, and the association with the administration of placebo or nortriptyline. The best results were obtained with educational intervention, in those patients having no personal history of depression, who sosa received the active drug. A negative history of depression was, however, the most important factor for the success of the treatment. Jorenby et al, (30) in a study of the use of bupropion, placebo, the nicotine sosa patch, or the nicotine patch plus bupropion in 893 individuals, excluded patients sosa having a previous history of several psychiatric pathologies (eg, panic, psychoses, bipolar disorder, alimentary disorder, dependence on psychoactive drugs, and alcohol). A significant difference in the rate of smoking cessation was observed, sosa as follows: nicotine patch, 48.0%; bupropion, 60.2%; nicotine patch plus bupropion, 66.5%; placebo, sosa 33.8%. The exclusion of a large portion of the psychiatric population sosa could account for the effectiveness of the medications used in this study, compared to the study by Hurt et al (16) with bupropion.

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